Drug Targets
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Plasma membrane
- Cell membrane Curated; Single-pass type I membrane protein Curated
-
Extracellular region or secreted
-
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
-
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- integral component of presynaptic membrane Source: GO_Central
- plasma membrane Source: Reactome
-
Other locations
- glutamatergic synapse Source: Ensembl
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| alda-1 | aldehyde dehydrogenase activator | Preclinical | PubMed Search | NA | 831629 | CHEMBL465952 |
| coenzyme-I | NA | Phase 2 | Integrity | DB00157 | NA | NA |
| CVT-10216 | aldehyde dehydrogenase inhibitor | Phase 1 | guidebook | NA | NA | NA |
| daidzin | antioxidant | Phase 1 | ClinicalTrials | DB02115 | NA | CHEMBL486422 |
| diphenyleneiodonium | nitric oxide synthase inhibitor | Preclinical | PubMed Search | NA | 3101 | CHEMBL365739 |
| disulfiram,disulfiram,disulfiram | aldehyde dehydrogenase inhibitor,DNA methyltransferase inhibitor,TRPV agonist | Launched,Launched,Launched | FDA Orange Book: disulfiram,FDA Orange Book: disulfiram,FDA Orange Book: disulfiram | DB00822,DB00822,DB00822 | 3117,3117,3117 | CHEMBL964,CHEMBL964,CHEMBL964 |
| guanidine | HSP inhibitor | Launched | FDA Orange Book: guanidine hydrochloride | DB00536 | NA | CHEMBL821 |
| nadide | free radical scavenger | Launched | drugs.com | NA | 5893 | NA |
| thioctic-acid | reducing agent | Launched | ClinicalTrials | DB166 | NA | CHEMBL1234071 |
10 best STRING interaction
-
Mitochondrion
-
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
-
Mitochondrion
- mitochondrial matrix Source: Reactome
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Extracellular region or secreted
-
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| dexamethasone | glucocorticoid receptor agonist | Launched | FDA Orange Book: dexamethasone | DB01234 | 5702035570203623670230037370740257434046954040469526 | CHEMBL384467 |
| hydrocortisone | glucocorticoid receptor agonist | Launched | FDA Orange Book: hydrocortisone | DB00741 | 5702068570206966024425320346450061452369421457543640 | CHEMBL389621 |
10 best STRING interaction
-
Endosome
- Endosome membrane By similarity; Peripheral membrane protein By similarity
- Early endosome By similarity
-
Extracellular region or secreted
- Secreted 3 Publications
- extracellular space 1 Publication
- extracellular exosome 1 Publication
-
Plasma membrane
- Cell membrane 1 Publication
- Basolateral cell membrane By similarity
- Apical cell membrane By similarity
- Lateral cell membrane By similarity
- Cell membrane 3 Publications; Peripheral membrane protein 3 Publications; Extracellular side 3 Publications
-
Nucleus
- Nucleus 2 Publications
-
Other locations
- Cytoplasm 3 Publications
- cilium By similarity
- Membrane 3 Publications; Peripheral membrane protein 2 Publications
- secretory vesicle lumen 1 Publication
- phagocytic cup By similarity
- Cytoplasmic vesicle membrane By similarity; Peripheral membrane protein By similarity
Note: Secreted, at least in part via exosomes and other secretory vesicles. Detected in exosomes and other extracellular vesicles (PubMed:25664854). Alternatively, the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in the protein translocation from the cytoplasm into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). Detected in gelatinase granules in resting neutrophils (PubMed:10772777). Secretion is increased in response to wounding and inflammation (PubMed:25664854). Secretion is increased upon T-cell activation (PubMed:17008549). Neutrophil adhesion to endothelial cells stimulates secretion via gelatinase granules, but foreign particle phagocytosis has no effect (PubMed:10772777). Colocalizes with actin fibers at phagocytic cups (By similarity). Displays calcium-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678).By similarity6 Publications
-
Cytosol
- cytosol Source: HPA
-
Endosome
- early endosome membrane Source: UniProtKB
- endosome Source: UniProtKB
- extrinsic component of endosome membrane Source: UniProtKB
-
Extracellular region or secreted
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
- extracellular space Source: UniProtKB
-
Lysosome
- mast cell granule Source: Ensembl
-
Mitochondrion
- mitochondrial membrane Source: Ensembl
-
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: BHF-UCL
-
Plasma Membrane
- apical plasma membrane Source: UniProtKB
- basolateral plasma membrane Source: UniProtKB-SubCell
- cornified envelope Source: UniProtKB
- extrinsic component of external side of plasma membrane Source: UniProtKB
- lateral plasma membrane Source: UniProtKB
- phagocytic cup Source: UniProtKB-SubCell
- plasma membrane Source: HPA
- sarcolemma Source: Ensembl
- synaptic membrane Source: Ensembl
-
Other locations
- adherens junction Source: BHF-UCL
- cell surface Source: BHF-UCL
- cytoplasm Source: UniProtKB
- cytoplasmic vesicle membrane Source: UniProtKB-SubCell
- extrinsic component of membrane Source: UniProtKB
- focal adhesion Source: UniProtKB
- motile cilium Source: UniProtKB
- protein-containing complex Source: Ensembl
- vesicle Source: UniProtKB
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Cytosol
- cytosol Source: HPA
-
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
-
Plasma Membrane
- plasma membrane Source: UniProtKB
-
Other locations
- axon Source: Ensembl
- cytoplasm Source: UniProtKB
- dendrite Source: Ensembl
- membrane Source: UniProtKB
- neuronal cell body Source: Ensembl
- phagocytic vesicle membrane Source: UniProtKB
- specific granule Source: UniProtKB
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| L-glutamic-acid | glutamate receptor agonist | Launched | FDA | DB00142 | NA | CHEMBL575060 |
| L-leucine | NA | Phase 3 | ClinicalTrials | DB00149 | NA | CHEMBL291962 |
| MC-1 | NA | Phase 3 | ClinicalTrials | DB00114 | NA | CHEMBL82202 |
10 best STRING interaction
-
Other locations
-
Cytosol
- cytosol Source: Reactome
-
Mitochondrion
- mitochondrion Source: GO_Central
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Nucleus
-
Other locations
- Cytoplasm By similarity
- perinuclear region By similarity
Note: Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation.By similarity
-
Cytosol
- cytosol Source: HPA
-
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
-
Plasma Membrane
- plasma membrane Source: HPA
-
Other locations
- Bcl3-Bcl10 complex Source: UniProtKB
- Bcl3/NF-kappaB2 complex Source: UniProtKB
- cytoplasm Source: UniProtKB
- intracellular membrane-bounded organelle Source: HPA
- midbody Source: HPA
- perinuclear region of cytoplasm Source: UniProtKB-SubCell
- protein-containing complex Source: UniProtKB
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| AT-406 | IAP antagonist | Phase 1 | ClinicalTrials | NA | NA | CHEMBL2158051 |
| AZD5582 | XIAP inhibitor | Preclinical | PubMed Search | NA | NA | CHEMBL3108827 |
| birinapant | XIAP inhibitor | Phase 2 | ClinicalTrials | DB11782 | NA | CHEMBL3039522 |
| GDC-0152 | XIAP inhibitor | Phase 1 | ClinicalTrials | DB12380 | NA | CHEMBL2063869 |
| SM-164 | XIAP inhibitor | Preclinical | PubMed Search | NA | NA | CHEMBL1774154 |
10 best STRING interaction
-
Cytosol
- cytosol Source: HPA
-
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
-
Other locations
- cytoplasm Source: UniProtKB
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Extracellular region or secreted
-
Extracellular region or secreted
- collagen-containing extracellular matrix Source: BHF-UCL
- complement component C1 complex Source: ProtInc
- extracellular region Source: Reactome
-
Other locations
- collagen trimer Source: UniProtKB-KW
- postsynapse Source: ARUK-UCL
- synapse Source: ARUK-UCL
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Cytoskeleton
- keratin filament Source: Ensembl
-
Cytosol
- cytosol Source: HPA
-
Mitochondrion
- mitochondrion Source: HPA
-
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: CACAO
-
Other locations
- cytoplasm Source: CACAO
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Plasma membrane
-
Golgi apparatus
-
Nucleus
-
Other locations
Note: Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By similarity). Tyr-27-phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments.By similarity
-
Golgi apparatus
- Golgi apparatus Source: BHF-UCL
- Golgi membrane Source: UniProtKB-SubCell
-
Nucleus
- nucleus Source: UniProtKB-SubCell
-
Plasma Membrane
- caveola Source: BHF-UCL
- caveolar macromolecular signaling complex Source: Ensembl
- extrinsic component of cytoplasmic side of plasma membrane Source: BHF-UCL
- integral component of plasma membrane Source: MGI
- plasma membrane Source: BHF-UCL
-
Other locations
- acrosomal membrane Source: Ensembl
- cytoplasmic vesicle Source: MGI
- focal adhesion Source: Ensembl
- membrane Source: BHF-UCL
- membrane raft Source: HGNC-UCL
- perinuclear region of cytoplasm Source: BHF-UCL
- protein-containing complex Source: MGI
- transport vesicle Source: LIFEdb
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Extracellular region or secreted
- Secreted 1 Publication
-
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA,NA | NA,NA | NA,NA | NA,NA | NA,NA | NA,NA | NA,NA |
10 best STRING interaction
-
Extracellular region or secreted
-
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Nucleus
- Nucleus By similarity
-
Cytoskeleton
- microtubule cytoskeleton Source: LIFEdb
-
Cytosol
- cytosol Source: ProtInc
-
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: GO_Central
-
Other locations
- cyclin A1-CDK2 complex Source: Ensembl
- cyclin A2-CDK2 complex Source: UniProtKB
- cyclin-dependent protein kinase holoenzyme complex Source: GO_Central
- cytoplasm Source: GO_Central
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| 5-fluorouracil | thymidylate synthase inhibitor | Launched | drugs.com | DB00544 | NA | CHEMBL185 |
| hyaluronic-acid | NA | Launched | drugs.com | NA | NA | CHEMBL2110674 |
10 best STRING interaction
-
Plasma membrane
- Cell membrane 2 Publications; Single-pass type I membrane protein Sequence analysis
-
Other locations
- microvillus By similarity
Note: Colocalizes with actin in membrane protrusions at wounding edges. Co-localizes with RDX, EZR and MSN in microvilli. Localizes to cholesterol-rich membrane-bound lipid raft domains.By similarity1 Publication
-
Cytosol
- cytosol Source: HPA
-
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
-
Golgi apparatus
- Golgi apparatus Source: HPA
-
Plasma Membrane
- apical plasma membrane Source: UniProtKB
- basolateral plasma membrane Source: GO_Central
- integral component of plasma membrane Source: UniProtKB
- lamellipodium membrane Source: UniProtKB
- plasma membrane Source: UniProtKB
-
Other locations
- cell projection Source: UniProtKB
- cell surface Source: UniProtKB
- focal adhesion Source: UniProtKB
- macrophage migration inhibitory factor receptor complex Source: BHF-UCL
- microvillus Source: UniProtKB
- secretory granule membrane Source: Reactome
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Plasma membrane
-
Plasma Membrane
- external side of plasma membrane Source: Ensembl
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: MGI
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Other locations
- Membrane 1 Publication; Single-pass type II membrane protein Sequence analysis
-
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
-
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: HGNC-UCL
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| exherin | cadherin antagonist | Phase 2 | ClinicalTrials | NA | NA | NA |
10 best STRING interaction
-
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein Sequence analysis
- sarcolemma By similarity
-
Other locations
- Cell junction 1 Publication
- Cell surface By similarity
Note: Colocalizes with TMEM65 at the intercalated disk in cardiomyocytes. Colocalizes with OBSCN at the intercalated disk and at sarcolemma in cardiomyocytes.By similarity
-
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
-
Extracellular region or secreted
- collagen-containing extracellular matrix Source: BHF-UCL
-
Plasma Membrane
- apical plasma membrane Source: Ensembl
- apicolateral plasma membrane Source: Ensembl
- basolateral plasma membrane Source: Ensembl
- catenin complex Source: BHF-UCL
- integral component of plasma membrane Source: UniProtKB
- integral component of postsynaptic specialization membrane Source: GO_Central
- integral component of presynaptic active zone membrane Source: GO_Central
- plasma membrane Source: UniProtKB
- plasma membrane raft Source: Ensembl
- sarcolemma Source: UniProtKB-SubCell
-
Other locations
- adherens junction Source: UniProtKB
- apical part of cell Source: GO_Central
- cell junction Source: UniProtKB
- cell surface Source: UniProtKB
- cell-cell junction Source: BHF-UCL
- cytoplasm Source: UniProtKB
- fascia adherens Source: Ensembl
- focal adhesion Source: UniProtKB
- intercalated disc Source: BHF-UCL
- lamellipodium Source: UniProtKB
- neuron projection Source: GO_Central
- postsynaptic density Source: GO_Central
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| aceneuramic-acid | NA | Phase 3 | ClinicalTrials | DB04265 | NA | CHEMBL165084 |
| apoptosis-activator-II | carboxylesterase inhibitor | Preclinical | PubMed Search | NA | 1901244 | CHEMBL375126 |
| avasimibe | ACAT inhibitor | Phase 3 | PubMed | DB06442 | NA | CHEMBL101309 |
| benzoin | NA | Preclinical | PubMed Search | NA | NA | CHEMBL19677 |
| cholic-acid | bile acid | Launched | FDA | DB02659 | 221493 | CHEMBL205596 |
| CI-976 | ACAT inhibitor | Phase 1 | Pharmaprojects | NA | 122327 | CHEMBL22373 |
| oseltamivir-phosphate | neuraminidase inhibitor | Launched | FDA Orange Book: oseltamivir phosphate | DB00198 | NA | CHEMBL1229 |
| probucol | atherogenesis inhibitor | Launched | FDA Orange Book: probucol | DB01599 | 4912 | CHEMBL608 |
10 best STRING interaction
-
Endoplasmic reticulum
- Endoplasmic reticulum lumen 1 Publication
-
Other locations
- Cytoplasm 1 Publication
- Lipid droplet 1 Publication
Note: Moves from cytoplasm to lipid droplets upon lipid loading. Associates with lipid droplets independently of triglycerides (TG) content of the droplets and hydrolyzes cholesteryl esters more efficiently from mixed droplets.1 Publication
-
Cytosol
- cytosol Source: GOC
-
Endoplasmic reticulum
- endoplasmic reticulum Source: HPA
- endoplasmic reticulum lumen Source: Reactome
-
Extracellular region or secreted
- extracellular space Source: GO_Central
-
Other locations
- cytoplasm Source: UniProtKB
- lipid droplet Source: UniProtKB
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Extracellular region or secreted
- Secreted By similarity
-
Other locations
- secretory vesicle By similarity
Note: Pyroglutaminated serpinin localizes to secretory vesicle.By similarity
-
Extracellular region or secreted
- Secreted By similarity
-
Other locations
- secretory vesicle By similarity
- neuronal dense core vesicle By similarity
Note: Associated with the secretory granule membrane through direct interaction to SCG3 that in turn binds to cholesterol-enriched lipid rafts in intragranular conditions. In pituitary gonadotropes, located in large secretory granules.By similarity
-
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: BHF-UCL
-
Other locations
- chromaffin granule Source: BHF-UCL
- neuronal dense core vesicle Source: UniProtKB
- perinuclear region of cytoplasm Source: UniProtKB
- secretory granule Source: BHF-UCL
- transport vesicle Source: UniProtKB-SubCell
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| creatine | NA | Launched | drugs.com | DB00148 | NA | CHEMBL283800 |
10 best STRING interaction
-
Other locations
-
Cytosol
- cytosol Source: HPA
-
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular space Source: AgBase
-
Nucleus
- nucleus Source: Ensembl
-
Other locations
- dendrite Source: Ensembl
- neuronal cell body Source: Ensembl
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Extracellular region or secreted
- extracellular matrix By similarity
-
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
-
Extracellular region or secreted
- basement membrane Source: GO_Central
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular matrix Source: GO_Central
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
-
Other locations
- collagen type IX trimer Source: BHF-UCL
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Lysosome
-
Extracellular region or secreted
- extracellular space Source: UniProtKB
-
Lysosome
- lysosome Source: UniProtKB-SubCell
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| boceprevir | HCV inhibitor | Launched | FDA Orange Book: boceprevir | NA | NA | CHEMBL1233448 |
| E-64,E-64 | calpain inhibitor,cysteine protease inhibitor | Preclinical,Preclinical | PubMed Search,PubMed Search | NA,NA | NA,NA | CHEMBL374508,CHEMBL374508 |
| LY3000328 | cathepsin inhibitor | Phase 1 | ClinicalTrials | NA | NA | CHEMBL3342553 |
| VBY-825 | cathepsin inhibitor | Preclinical | PubMed Search | NA | NA | NA |
10 best STRING interaction
-
Endosome
- endolysosome lumen Source: Reactome
- late endosome Source: ARUK-UCL
-
Extracellular region or secreted
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular region Source: Reactome
- extracellular space Source: UniProtKB
-
Lysosome
- endolysosome lumen Source: Reactome
- lysosomal lumen Source: Reactome
- lysosome Source: UniProtKB
-
Other locations
- ficolin-1-rich granule lumen Source: Reactome
- intracellular membrane-bounded organelle Source: HPA
- phagocytic vesicle Source: UniProtKB
- tertiary granule lumen Source: Reactome
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Extracellular region or secreted
- Secreted 1 Publication
-
Extracellular region or secreted
- extracellular region Source: BHF-UCL
- extracellular space Source: GO_Central
-
Plasma Membrane
- external side of plasma membrane Source: Ensembl
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| laquinimod | immunosuppressant | Phase 3 | ClinicalTrials | DB06685 | NA | CHEMBL66092 |
10 best STRING interaction
-
Extracellular region or secreted
-
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Extracellular region or secreted
-
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
-
Plasma Membrane
- external side of plasma membrane Source: Ensembl
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| AZD5069 | CC chemokine receptor antagonist | Phase 2 | ClinicalTrials | NA | NA | NA |
| AZD8797 | CC chemokine receptor antagonist | Preclinical | PubMed Search | NA | NA | CHEMBL2349310 |
| danirixin | CC chemokine receptor antagonist | Phase 2 | ClinicalTrials | DB11922 | NA | CHEMBL3039531 |
| indoprofen,indoprofen | cyclooxygenase inhibitor,prostanoid receptor antagonist | Withdrawn,Withdrawn | Wikipedia,Wikipedia | NA,NA | 3718,3718 | CHEMBL264931,CHEMBL264931 |
| navarixin | CC chemokine receptor antagonist | Phase 2 | ClinicalTrials | NA | NA | CHEMBL216981 |
| reparixin | CC chemokine receptor antagonist | Phase 3 | ClinicalTrials | DB12614 | NA | CHEMBL191413 |
| SB-225002 | CC chemokine receptor antagonist | Preclinical | PubMed Search | NA | 3854666 | CHEMBL239767 |
| SRT3190 | CC chemokine receptor antagonist | Preclinical | PubMed Search | NA | NA | NA |
10 best STRING interaction
-
Plasma membrane
-
Cytoskeleton
- microtubule cytoskeleton Source: HPA
- mitotic spindle Source: HPA
-
Lysosome
- mast cell granule Source: UniProtKB
-
Nucleus
- nucleoplasm Source: HPA
-
Plasma Membrane
- external side of plasma membrane Source: GO_Central
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: HPA
-
Other locations
- cell surface Source: UniProtKB
- membrane Source: UniProtKB
- secretory granule membrane Source: Reactome
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Other locations
- Cytoplasm By similarity
-
Other locations
- cytoplasm Source: BHF-UCL
- cytoplasmic vesicle Source: BHF-UCL
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
- extracellular space Source: UniProtKB
- microvesicle Source: UniProtKB
-
Golgi apparatus
- Golgi lumen Source: Reactome
-
Other locations
- extrinsic component of membrane Source: UniProtKB
- sperm midpiece Source: UniProtKB
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Other locations
- Membrane Curated; Single-pass type I membrane protein Curated
-
Other locations
- integral component of membrane Source: UniProtKB
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Cytosol
- cytosol Source: Reactome
-
Other locations
- cytoplasm Source: GO_Central
- intracellular membrane-bounded organelle Source: GO_Central
- postsynaptic density Source: GO_Central
- presynapse Source: GOC
- vesicle Source: GO_Central
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| desidustat | hypoxia inducible factor prolyl hydroxylase inhibitor | Preclinical | PubMed Search | NA | NA | NA |
| FG-2216 | hypoxia inducible factor prolyl hydroxylase inhibitor | Phase 2 | ClinicalTrials | DB08687 | NA | CHEMBL426560 |
| FG-4592 | hypoxia inducible factor prolyl hydroxylase inhibitor | Phase 3 | ClinicalTrials | DB04847 | NA | CHEMBL2338329 |
| MK-8617 | hypoxia inducible factor prolyl hydroxylase inhibitor | Preclinical | PubMed Search | NA | NA | NA |
| molidustat | hypoxia inducible factor inhibitor | Phase 3 | ClinicalTrials | NA | NA | CHEMBL3646118 |
| vadadustat | hypoxia inducible factor prolyl hydroxylase inhibitor | Phase 3 | ClinicalTrials | DB12255 | NA | CHEMBL3646221 |
10 best STRING interaction
-
Nucleus
- Nucleus 4 Publications
-
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
-
Other locations
- cytoplasm Source: GO_Central
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| methyl-aminolevulinate | oxidizing agent | Launched | FDA Orange Book: methyl aminolevulinate hydrochloride | DB00992 | NA | CHEMBL1096562 |
10 best STRING interaction
-
Plasma membrane
- Cell membrane 2 Publications; Single-pass type I membrane protein 2 Publications
Note: Stabilized at the cell membrane through interaction with FCER1G.
-
Endosome
- early endosome membrane Source: Reactome
-
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: BHF-UCL
-
Other locations
- clathrin-coated endocytic vesicle membrane Source: Reactome
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Extracellular region or secreted
- Secreted Curated
-
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: UniProtKB
-
Nucleus
- nucleus Source: UniProtKB
-
Plasma Membrane
- plasma membrane Source: UniProtKB
-
Other locations
- cell surface Source: UniProtKB
- cytoplasm Source: GO_Central
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Extracellular region or secreted
- Secreted Curated
-
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
-
Other locations
- cytoplasm Source: GO_Central
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Nucleus
-
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleolus Source: HPA
- nucleus Source: GO_Central
-
Other locations
- intracellular membrane-bounded organelle Source: HPA
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
Note: Relocalizes DVL1 to the cell membrane leading to phosphorylation of DVL1 and AXIN1 relocalization to the cell membrane.By similarity
-
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB
-
Golgi apparatus
- Golgi apparatus Source: UniProtKB
-
Mitochondrion
- mitochondrial membrane Source: UniProtKB
-
Plasma Membrane
- filopodium membrane Source: Ensembl
- plasma membrane Source: UniProtKB
-
Other locations
- cell surface Source: BHF-UCL
- cytoplasm Source: BHF-UCL
- glutamatergic synapse Source: Ensembl
- integral component of membrane Source: GO_Central
- perinuclear region of cytoplasm Source: Ensembl
- postsynapse Source: Ensembl
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Other locations
- Cytoplasm 1 Publication
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Extracellular region or secreted
- Secreted 1 Publication
-
Other locations
- secretory vesicle lumen By similarity
-
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: UniProtKB
-
Other locations
- secretory granule lumen Source: UniProtKB
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Extracellular region or secreted
- Secreted 1 Publication
-
Other locations
- Cytoplasmic granule 1 Publication
Note: Delivered into the target cell by perforin.2 Publications
-
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
-
Nucleus
- nucleus Source: UniProtKB
-
Plasma Membrane
- immunological synapse Source: UniProtKB
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Nucleus
- Nucleus 1 Publication
-
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: GO_Central
-
Other locations
- chromatin Source: UniProtKB
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Cytosol
- cytosol Source: HPA
-
Nucleus
- nuclear body Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
-
Other locations
- chaperone complex Source: ARUK-UCL
- cytoplasm Source: UniProtKB
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Nucleus
-
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
-
Other locations
- cytoplasm Source: Ensembl
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Nucleus
- Nucleus inner membrane 2 Publications; Multi-pass membrane protein Sequence analysis
-
Mitochondrion
- Mitochondrion membrane 2 Publications; Multi-pass membrane protein Sequence analysis
-
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Note: Exclusive localizations in either the nucleus or the mitochondrion have been reported.2 Publications
-
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
-
Mitochondrion
- mitochondrial membrane Source: UniProtKB
- mitochondrial outer membrane Source: Reactome
- mitochondrion Source: GO_Central
-
Nucleus
- nuclear envelope Source: UniProtKB
- nuclear inner membrane Source: MGI
-
Other locations
- integral component of membrane Source: UniProtKB-KW
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Extracellular region or secreted
-
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| AS-2034178 | free fatty acid receptor agonist | Preclinical | PubMed Search | NA | NA | NA |
| azilsartan | angiotensin receptor antagonist | Launched | FDA Orange Book: azilsartan kamedoxomil | NA | NA | CHEMBL57242 |
| azilsartan-medoxomil | angiotensin receptor antagonist | Launched | Wikipedia | DB08822 | NA | CHEMBL2028661 |
| balaglitazone,balaglitazone | insulin sensitizer,PPAR receptor partial agonist | Phase 3,Phase 3 | ClinicalTrials,ClinicalTrials | NA,NA | NA,NA | CHEMBL213991,CHEMBL213991 |
| BETP | GLP receptor positive allosteric modulator | Preclinical | PubMed Search | NA | NA | NA |
| ciglitazone | PPAR receptor agonist | Phase 2 | Springer | NA | 2750 | CHEMBL1398683 |
| darglitazone | PPAR receptor antagonist | Phase 2 | PubMed | DB14034 | NA | CHEMBL55624 |
| edaglitazone | PPAR receptor agonist | Phase 2 | Springer | NA | NA | NA |
| exenatide | GLP receptor agonist | Launched | FDA Orange Book: exenatide synthetic | NA | NA | CHEMBL414357 |
| GW-0742 | PPAR receptor agonist | Preclinical | PubMed Search | NA | 9934458 | CHEMBL38508 |
| GW-1929 | PPAR receptor agonist | Preclinical | PubMed Search | NA | 4516886 | CHEMBL434063 |
| GW-501516 | PPAR receptor agonist | Phase 2 | ClinicalTrials | DB05416 | 9803963 | CHEMBL38943 |
| ID-1101 | insulin sensitizer | Phase 1 | Unexpected Source | NA | NA | CHEMBL508094 |
| kuromanin | ribosyl cyclase inhibitor | Preclinical | PubMed Search | NA | NA | CHEMBL257839 |
| liraglutide | GLP receptor agonist | Launched | FDA Orange Book: liraglutide recombinant | NA | NA | CHEMBL4084119 |
| lupanine | sodium channel blocker | Phase 1 | PubMed | NA | 6708718 | CHEMBL459396 |
| metacresol | NA | Launched | drugs.com | DB01776 | NA | CHEMBL298312 |
| metformin | insulin sensitizer | Launched | FDA Orange Book: metformin hydrochloride | DB00331 | 4091 | CHEMBL1431 |
| methazolamide | carbonic anhydrase inhibitor | Launched | FDA Orange Book: methazolamide | DB00703 | 4100 | CHEMBL1335656 |
| mitiglinide | insulin secretagogue | Launched | ClinicalTrials | DB01252 | NA | CHEMBL471498 |
| MSDC-0160 | insulin sensitizer | Phase 2 | ClinicalTrials | NA | NA | NA |
| nateglinide | insulin secretagogue | Launched | FDA Orange Book: nateglinide | DB00731 | 600265311309 | CHEMBL783 |
| NO-ASA | cyclooxygenase inhibitor | Phase 2 | ClinicalTrials | DB12445 | 119032 | CHEMBL374385 |
| pioglitazone,pioglitazone | insulin sensitizer,PPAR receptor agonist | Launched,Launched | FDA Orange Book: pioglitazone hydrochloride,FDA Orange Book: pioglitazone hydrochloride | DB1132,DB1132 | 60560,60560 | CHEMBL595,CHEMBL595 |
| repaglinide | insulin secretagogue | Launched | FDA Orange Book: repaglinide | DB00912 | 65981 | CHEMBL1272 |
| rosiglitazone,rosiglitazone | insulin sensitizer,PPAR receptor agonist | Withdrawn,Withdrawn | Wikipedia,Wikipedia | DB412,DB412 | 77999,77999 | CHEMBL333304,CHEMBL333304 |
| S26948 | PPAR receptor agonist | Preclinical | PubMed Search | NA | NA | NA |
| TAK-875 | insulin secretagogue | Phase 3 | ClinicalTrials | DB12491 | NA | CHEMBL1829174 |
| tesaglitazar,tesaglitazar | insulin sensitizer,PPAR receptor agonist | Phase 3,Phase 3 | ClinicalTrials,ClinicalTrials | DB06536,DB06536 | NA,NA | CHEMBL282686,CHEMBL282686 |
| troglitazone,troglitazone | insulin sensitizer,PPAR receptor agonist | Withdrawn,Withdrawn | Wikipedia,Wikipedia | DB08607,DB08607 | 5591,5591 | CHEMBL48,CHEMBL48 |
10 best STRING interaction
-
Extracellular region or secreted
-
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
-
Endosome
- endosome lumen Source: Reactome
-
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: BHF-UCL
-
Golgi apparatus
- Golgi lumen Source: Reactome
- Golgi membrane Source: Reactome
-
Other locations
- endoplasmic reticulum-Golgi intermediate compartment membrane Source: Reactome
- secretory granule lumen Source: Reactome
- transport vesicle Source: Reactome
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Cytosol
- cytosol Source: Reactome
- cytosolic small ribosomal subunit Source: GO_Central
-
Extracellular region or secreted
- extracellular region Source: UniProtKB
-
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: GO_Central
-
Other locations
- cytoplasm Source: GO_Central
- small ribosomal subunit Source: GO_Central
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Nucleus
- Nucleus By similarity
-
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleus Source: GO_Central
-
Other locations
- cytoplasm Source: BHF-UCL
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein Curated
-
Other locations
- Membrane raft 1 Publication; Single-pass type I membrane protein Curated
-
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular space Source: UniProtKB
-
Plasma Membrane
- external side of plasma membrane Source: ARUK-UCL
- integrin alphaM-beta2 complex Source: ARUK-UCL
- integrin complex Source: ProtInc
- plasma membrane Source: UniProtKB
- plasma membrane raft Source: UniProtKB
-
Other locations
- cell surface Source: UniProtKB
- specific granule membrane Source: Reactome
- tertiary granule membrane Source: Reactome
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Plasma membrane
-
Other locations
Note: Colocalizes with DST at the leading edge of migrating keratinocytes.
-
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
-
Nucleus
- nuclear membrane Source: HPA
- nucleolus Source: HPA
-
Plasma Membrane
- integrin complex Source: ProtInc
- plasma membrane Source: UniProtKB
-
Other locations
- cell junction Source: HPA
- cell leading edge Source: UniProtKB
- cell surface Source: UniProtKB
- focal adhesion Source: GO_Central
- hemidesmosome Source: UniProtKB
- receptor complex Source: MGI
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Plasma membrane
- Cell membrane 2 Publications; Single-pass type II membrane protein Sequence analysis
-
Plasma Membrane
- external side of plasma membrane Source: Ensembl
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: Reactome
-
Other locations
- receptor complex Source: UniProtKB
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Other locations
- Cytoplasm By similarity
-
Cytoskeleton
- intermediate filament Source: UniProtKB-KW
- intermediate filament cytoskeleton Source: HPA
-
Cytosol
- cytosol Source: Reactome
-
Other locations
- cell periphery Source: Ensembl
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Cytoskeleton
- intermediate filament Source: BHF-UCL
- keratin filament Source: MGI
-
Cytosol
- cytosol Source: Reactome
-
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
-
Nucleus
- nucleus Source: UniProtKB
-
Plasma Membrane
- plasma membrane Source: Ensembl
-
Other locations
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Plasma membrane
- Cell membrane 4 Publications; Single-pass type I membrane protein By similarity
-
Other locations
- growth cone By similarity
- axon 1 Publication
- dendrite
Note: Colocalized with SHTN1 in close apposition with actin filaments in filopodia and lamellipodia of axonalne growth cones of hippocampal neurons (By similarity). In neurons, detected predominantly in axons and cell body, weak localization to dendrites (PubMed:20621658).By similarity1 Publication
-
Extracellular region or secreted
- collagen-containing extracellular matrix Source: BHF-UCL
-
Plasma Membrane
- plasma membrane Source: UniProtKB
-
Other locations
- axon Source: UniProtKB
- axonal growth cone Source: UniProtKB
- cell surface Source: UniProtKB
- dendrite Source: UniProtKB-SubCell
- focal adhesion Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
- neuronal cell body Source: UniProtKB
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Extracellular region or secreted
-
Extracellular region or secreted
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular region Source: Reactome
- laminin complex Source: GO_Central
- laminin-5 complex Source: Ensembl
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Extracellular region or secreted
-
Extracellular region or secreted
- laminin complex Source: GO_Central
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Other locations
- Cytoplasm By similarity
-
Cytoskeleton
- centrosome By similarity
- spindle pole By similarity
-
Nucleus
- Nucleus envelope By similarity
-
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Single-pass type IV membrane protein Sequence analysis
-
Other locations
- Chromosome By similarity
Note: Colocalized with ITPR3 on the endoplasmic reticulum membrane.By similarity
-
Cytoskeleton
- microtubule organizing center Source: UniProtKB-SubCell
- spindle pole Source: UniProtKB-SubCell
-
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB
-
Lysosome
- azurophil granule membrane Source: Reactome
-
Nucleus
- nuclear envelope Source: UniProtKB
-
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: Reactome
-
Other locations
- chromosome Source: UniProtKB-SubCell
- integral component of membrane Source: ProtInc
- membrane Source: UniProtKB
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Extracellular region or secreted
- extracellular matrix 2 Publications
-
Extracellular region or secreted
- collagen-containing extracellular matrix Source: UniProtKB
- extracellular matrix Source: UniProtKB
- extracellular region Source: BHF-UCL
- extracellular space Source: BHF-UCL
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
Subcellular figure not found
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| marimastat | matrix metalloprotease inhibitor | Phase 3 | ClinicalTrials | DB00786 | NA | CHEMBL279785 |
10 best STRING interaction
-
Extracellular region or secreted
- extracellular matrix Curated
-
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular matrix Source: InterPro
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
-
Other locations
- cell surface Source: Ensembl
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Plasma membrane
-
Golgi apparatus
-
Extracellular region or secreted
-
Extracellular region or secreted
-
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
-
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: Ensembl
-
Golgi apparatus
- Golgi apparatus Source: UniProtKB-SubCell
-
Plasma Membrane
- plasma membrane Source: Reactome
-
Other locations
- anchored component of membrane Source: UniProtKB-KW
- cell surface Source: GO_Central
- membrane Source: UniProtKB
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Endoplasmic reticulum
- Endoplasmic reticulum membrane 3 Publications; Peripheral membrane protein 1 Publication; Cytoplasmic side
-
Other locations
- Cytoplasm 4 Publications
- perinuclear region 1 Publication
Note: Binds preferentially to negatively charged phospholipids (PubMed:21900240). Colocalizes with CCHFV protein N in the perinuclear region (PubMed:15047845).2 Publications
-
Cytoskeleton
- microtubule cytoskeleton Source: GO_Central
-
Cytosol
- cytosol Source: HPA
-
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
-
Mitochondrion
- mitochondrial membrane Source: GO_Central
-
Nucleus
- nuclear membrane Source: HPA
- nucleus Source: GO_Central
-
Plasma Membrane
- plasma membrane Source: GO_Central
- postsynaptic endocytic zone membrane Source: GO_Central
- postsynaptic membrane Source: GO_Central
-
Other locations
- axon Source: GO_Central
- cytoplasm Source: UniProtKB
- cytoplasmic vesicle Source: GO_Central
- dendritic spine Source: GO_Central
- dendritic spine head Source: GO_Central
- membrane Source: GO_Central
- perinuclear region of cytoplasm Source: UniProtKB
- postsynaptic density Source: GO_Central
- presynapse Source: GOC
- synapse Source: GO_Central
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Nucleus
- Nucleus By similarity
-
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| AZD5153 | bromodomain inhibitor | Phase 1 | ClinicalTrials | NA | NA | CHEMBL4078100 |
| mivebresib | bromodomain inhibitor | Phase 1 | ClinicalTrials | NA | NA | CHEMBL3987016 |
| TWS-119 | glycogen synthase kinase inhibitor | Preclinical | PubMed Search | NA | 9549289 | CHEMBL405759 |
10 best STRING interaction
-
Nucleus
- nucleoplasm 1 Publication
- nucleolus 2 Publications
-
Nucleus
- nuclear chromatin Source: BHF-UCL
- nucleolus Source: UniProtKB
- nucleoplasm Source: UniProtKB
- nucleus Source: UniProtKB
-
Other locations
- protein-containing complex Source: UniProtKB
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Plasma membrane
-
Plasma membrane
-
Plasma membrane
-
Plasma membrane
- Cell membrane Curated; GPI-anchor Curated
-
Extracellular region or secreted
-
Extracellular region or secreted
- Secreted Curated
-
Cytosol
- cytosol Source: HPA
-
Extracellular region or secreted
- collagen-containing extracellular matrix Source: BHF-UCL
-
Golgi apparatus
- Golgi membrane Source: Reactome
-
Plasma Membrane
- external side of plasma membrane Source: MGI
- plasma membrane Source: HPA
-
Other locations
- anchored component of membrane Source: UniProtKB-KW
- cell surface Source: BHF-UCL
- integral component of membrane Source: ProtInc
- membrane Source: UniProtKB
- neuron projection Source: GO_Central
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Other locations
- Membrane 6 Publications; Single-pass type I membrane protein 6 Publications
- Cytoplasmic vesicle membrane 1 Publication; Single-pass type I membrane protein 6 Publications
- Melanosome 2 Publications
Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
-
Endoplasmic reticulum
- endoplasmic reticulum Source: HGNC-UCL
-
Endosome
- early endosome Source: Ensembl
- endosome membrane Source: Reactome
-
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
-
Golgi apparatus
- Golgi apparatus Source: HGNC-UCL
-
Lysosome
- azurophil granule membrane Source: Reactome
- lysosomal membrane Source: UniProtKB
-
Mitochondrion
- mitochondrion Source: Ensembl
-
Plasma Membrane
- gamma-secretase complex Source: UniProtKB
- integral component of plasma membrane Source: HGNC-UCL
- integral component of presynaptic membrane Source: Ensembl
- plasma membrane Source: Reactome
- sarcolemma Source: Ensembl
-
Other locations
- focal adhesion Source: UniProtKB
- integral component of membrane Source: UniProtKB
- melanosome Source: UniProtKB-SubCell
- membrane Source: UniProtKB
- synaptic vesicle Source: Ensembl
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Nucleus
- Nucleus By similarity
-
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleoplasm Source: UniProtKB
- nucleus Source: UniProtKB
-
Other locations
- transcription regulator complex Source: Ensembl
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Extracellular region or secreted
- extracellular matrix By similarity
-
Extracellular region or secreted
- collagen-containing extracellular matrix Source: InterPro
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
-
Golgi apparatus
- Golgi lumen Source: Reactome
-
Lysosome
- lysosomal lumen Source: Reactome
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| FRAX486 | serine/threonine kinase inhibitor | Preclinical | PubMed Search | NA | NA | CHEMBL3609326 |
10 best STRING interaction
-
Other locations
- Cytoplasm By similarity
-
Cytosol
- cytosol Source: Reactome
-
Endosome
- endosome Source: Ensembl
-
Plasma Membrane
- plasma membrane Source: Reactome
-
Other locations
- cytoplasm Source: GO_Central
- glutamatergic synapse Source: Ensembl
- postsynaptic density Source: Ensembl
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| GSK690693 | AKT inhibitor | Phase 1 | ClinicalTrials | DB12745 | NA | CHEMBL494089 |
10 best STRING interaction
-
Nucleus
-
Mitochondrion
-
Other locations
Note: Shuttles between the nucleus and the mitochondria, and mitochondrial localization is essential for the role in cell survival.
-
Mitochondrion
- mitochondrion Source: UniProtKB-SubCell
-
Nucleus
- nucleoplasm Source: HPA
-
Other locations
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Extracellular region or secreted
-
Extracellular region or secreted
- extracellular space Source: UniProtKB
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Nucleus
- Nucleus 1 Publication
-
Plasma membrane
- Cell membrane 1 Publication
-
Nucleus
- nucleoplasm Source: HPA
-
Plasma Membrane
- plasma membrane Source: HPA
-
Other locations
- cytoplasm Source: GO_Central
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Extracellular region or secreted
-
Endosome
- Endosome lumen 1 Publication
-
Plasma membrane
- Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications
-
Other locations
- Cytoplasmic granule lumen 1 Publication
Note: Stored in cytoplasmic granules of cytolytic T-lymphocytes and secreted into the cleft between T-lymphocyte and target cell (PubMed:20038786). Inserts into the cell membrane of target cells and forms pores (PubMed:20889983). Membrane insertion and pore formation requires a major conformation change (PubMed:20889983). May be taken up via endocytosis involving clathrin-coated vesicles and accumulate in a first time in large early endosomes (PubMed:20038786).2 Publications
-
Cytosol
- cytosol Source: HPA
-
Endosome
- endosome lumen Source: UniProtKB-SubCell
-
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
-
Lysosome
- cytolytic granule Source: UniProtKB
-
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
-
Other locations
- integral component of membrane Source: UniProtKB
- membrane Source: UniProtKB
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| 2-ethoxybenzoic-acid | analgesic agent | Phase 1 | Pharmaprojects | NA | NA | NA |
| aceclofenac | prostanoid receptor antagonist | Launched | drugs.com | DB06736 | 71771 | CHEMBL93645 |
| acemetacin | cyclooxygenase inhibitor | Launched | Wikipedia | DB13783 | 1981 | CHEMBL189171 |
| alclofenac | cyclooxygenase inhibitor | Launched | drugs.com | DB13167 | NA | CHEMBL94081 |
| alpha-linolenic-acid | omega 3 fatty acid stimulant | Phase 3 | ClinicalTrials | DB00132 | 5280934 | CHEMBL8739 |
| amfenac | cyclooxygenase inhibitor | Launched | drugs.com | NA | NA | CHEMBL25146 |
| aminosalicylate | cyclooxygenase inhibitor | Launched | FDA Orange Book: aminosalicylate sodium | DB00233 | NA | CHEMBL1169 |
| ampiroxicam | cyclooxygenase inhibitor | Launched | drugs.com | NA | 2176 | CHEMBL1566249 |
| amtolmetin-guacil | cyclooxygenase inhibitor | Launched | drugs.com | NA | NA | CHEMBL1766570 |
| apyramide | cyclooxygenase inhibitor | Preclinical | PubMed Search | NA | NA | CHEMBL97562 |
| arundic-acid | astrocyte modulating agent | Phase 2/Phase 3 | ClinicalTrials | DB05343 | NA | CHEMBL3187683 |
| asaraldehyde | cyclooxygenase inhibitor | Preclinical | PubMed Search | NA | NA | CHEMBL1164301 |
| aspirin | cyclooxygenase inhibitor | Launched | ClinicalTrials | DB00945 | 2244 | CHEMBL25 |
| azapropazone | cyclooxygenase inhibitor | Withdrawn | Wikipedia | NA | 26098 | CHEMBL1483341 |
| balsalazide | cyclooxygenase inhibitor | Launched | FDA Orange Book: balsalazide disodium | DB01014 | 6335412 | CHEMBL1201346 |
| bendazac | cyclooxygenase inhibitor | Launched | drugs.com | DB13501 | NA | CHEMBL1089221 |
| bromfenac | cyclooxygenase inhibitor | Withdrawn | Wikipedia | DB00963 | 60726 | CHEMBL1077 |
| butylidenephthalide | cyclooxygenase inhibitor | Phase 1/Phase 2 | ClinicalTrials | NA | NA | CHEMBL249592 |
| carprofen | cyclooxygenase inhibitor | Launched | FDA Orange Book: carprofen | DB821 | 2581 | CHEMBL2171250 |
| celecoxib | cyclooxygenase inhibitor | Launched | FDA Orange Book: celecoxib | DB00482 | 2662 | CHEMBL118 |
| cicloprofen | cyclooxygenase inhibitor | Preclinical | PubMed Search | NA | NA | CHEMBL214122 |
| clonixin | cyclooxygenase inhibitor | Preclinical | PubMed Search | DB09218 | NA | CHEMBL1332971 |
| cryptotanshinone,cryptotanshinone | acetylcholinesterase inhibitor,STAT inhibitor | Preclinical,Preclinical | PubMed Search,PubMed Search | DB15579,DB15579 | NA,NA | CHEMBL187460,CHEMBL187460 |
| curcumin,curcumin,curcumin,curcumin | cyclooxygenase inhibitor,histone acetyltransferase inhibitor,lipoxygenase inhibitor,NFkB pathway inhibitor | Launched,Launched,Launched,Launched | ClinicalTrials,ClinicalTrials,ClinicalTrials,ClinicalTrials | NA,NA,NA,NA | 167600395281767,167600395281767,167600395281767,167600395281767 | CHEMBL14,CHEMBL14,CHEMBL14,CHEMBL14 |
| deracoxib | cyclooxygenase inhibitor | Launched | drugs.com | DB11395 | 3058754 | CHEMBL28636 |
| diclofenac | cyclooxygenase inhibitor | Launched | FDA Orange Book: diclofenac | DB00586 | 5018304 | CHEMBL139 |
| diflunisal | prostanoid receptor antagonist | Launched | FDA Orange Book: diflunisal | DB00861 | 3059 | CHEMBL898 |
| dihomo-gamma-linolenic-acid | prostanoid receptor agonist | Phase 2 | PubMed | DB00154 | NA | CHEMBL465183 |
| doconexent | PPAR receptor agonist | Launched | drugs.com | DB03756 | 445580 | CHEMBL367149 |
| droxicam | cyclooxygenase inhibitor | Launched | Wikipedia | DB09215 | NA | CHEMBL1213420 |
| DUP-697 | cyclooxygenase inhibitor | Phase 1 | PubMed | NA | 3177 | CHEMBL42485 |
| epirizole | cyclooxygenase inhibitor | Launched | drugs.com | DB08991 | 3242 | CHEMBL1411693 |
| etodolac | cyclooxygenase inhibitor | Launched | FDA Orange Book: etodolac | DB749 | 330873707528667528 | CHEMBL1315939 |
| etofenamate | cyclooxygenase inhibitor | Launched | drugs.com | DB08984 | 35375 | CHEMBL1451633 |
| etoricoxib | cyclooxygenase inhibitor | Launched | drugs.com | DB01628 | 123619 | CHEMBL416146 |
| felbinac-ethyl | cyclooxygenase inhibitor | Launched | Springer | NA | NA | CHEMBL1886408 |
| fenbufen | cyclooxygenase inhibitor | Launched | drugs.com | DB08981 | 3335 | CHEMBL277522 |
| fentiazac | cyclooxygenase inhibitor | Launched | drugs.com | DB13217 | 28871 | CHEMBL589092 |
| firocoxib | cyclooxygenase inhibitor | Launched | drugs.com | DB09217 | NA | CHEMBL69998 |
| FK-3311 | cyclooxygenase inhibitor | Phase 2 | Pharmaprojects | NA | NA | NA |
| floctafenine | cyclooxygenase inhibitor | Launched | drugs.com | NA | NA | CHEMBL21575 |
| florifenine | anti-inflammatory agent | Preclinical | PubMed Search | NA | NA | CHEMBL2104893 |
| flufenamic-acid | chloride channel blocker | Preclinical | PubMed Search | DB02266 | 3371 | CHEMBL23588 |
| flurbiprofen-(+/-) | NA | NA | PubMed Search | NA | NA | NA |
| flurbiprofen-(S)-(+) | NA | NA | PubMed Search | NA | NA | NA |
| flurbiprofen-axetil | analgesic agent | Launched | FDA Orange Book: flurbiprofen axetil | NA | NA | NA |
| flurizan | gamma secretase inhibitor | Phase 3 | Wikipedia | DB05289 | NA | CHEMBL190083 |
| fosfosal | phosphodiesterase inhibitor | Launched | Pharmaprojects | NA | 3418 | CHEMBL287275 |
| gamma-linolenic-acid,gamma-linolenic-acid | cyclooxygenase inhibitor,prostanoid receptor agonist | Phase 2,Phase 2 | ClinicalTrials,ClinicalTrials | DB13854,DB13854 | NA,NA | CHEMBL464982,CHEMBL464982 |
| ginsenoside-C-K,ginsenoside-C-K | NFkB pathway inhibitor,nitric oxide synthase inhibitor | Phase 1,Phase 1 | ClinicalTrials,ClinicalTrials | NA,NA | NA,NA | CHEMBL3355096,CHEMBL3355096 |
| honokiol | AKT inhibitor | Phase 3 | ClinicalTrials | NA | 72303 | CHEMBL16901 |
| ibuprofen-(S) | cyclooxygenase inhibitor | Launched | ClinicalTrials | DB09213 | NA | CHEMBL175 |
| ibuprofen-lysine | cyclooxygenase inhibitor | Launched | FDA Orange Book: ibuprofen lysine | DB15 | NA | CHEMBL121141 |
| ibuprofen-piconol | cyclooxygenase inhibitor | Launched | drugs.com | NA | NA | CHEMBL216254 |
| ibuproxam,ibuproxam | cyclooxygenase inhibitor,prostaglandin inhibitor | Launched,Launched | Unexpected Source,Unexpected Source | NA,NA | NA,NA | CHEMBL190266,CHEMBL190266 |
| icosapent | platelet aggregation inhibitor | Launched | FDA Orange Book: icosapent ethyl | DB00159 | 446284 | CHEMBL460026 |
| idazoxan | adrenergic receptor antagonist | Phase 3 | ClinicalTrials | NA | NA | CHEMBL1316 |
| iguratimod,iguratimod | cyclooxygenase inhibitor,NFkB pathway inhibitor | Launched,Launched | ClinicalTrials,ClinicalTrials | DB12233,DB12233 | NA,NA | CHEMBL2107455,CHEMBL2107455 |
| indobufen,indobufen | cyclooxygenase inhibitor,platelet aggregation inhibitor | Launched,Launched | drugs.com,drugs.com | NA,NA | NA,NA | CHEMBL1765292,CHEMBL1765292 |
| indomethacin | cyclooxygenase inhibitor | Launched | FDA Orange Book: indomethacin | DB00328 | NA | CHEMBL6 |
| indoprofen,indoprofen | cyclooxygenase inhibitor,prostanoid receptor antagonist | Withdrawn,Withdrawn | Wikipedia,Wikipedia | NA,NA | 3718,3718 | CHEMBL264931,CHEMBL264931 |
| isoxicam | cyclooxygenase inhibitor | Withdrawn | Wikipedia | DB08942 | 54677972 | CHEMBL53292 |
| ketoprofen | cyclooxygenase inhibitor | Launched | FDA Orange Book: ketoprofen | DB19 | 3825 | CHEMBL372052 |
| ketorolac | cyclooxygenase inhibitor | Launched | FDA Orange Book: ketorolac tromethamine | DB465 | 3826 | CHEMBL469 |
| licofelone,licofelone | cyclooxygenase inhibitor,lipoxygenase inhibitor | Phase 3,Phase 3 | Wikipedia,Wikipedia | DB04725,DB04725 | NA,NA | CHEMBL300982,CHEMBL300982 |
| lornoxicam | cyclooxygenase inhibitor | Launched | drugs.com | DB06725 | NA | CHEMBL1569487 |
| loxoprofen,loxoprofen | cyclooxygenase inhibitor,prostanoid receptor antagonist | Launched,Launched | drugs.com,drugs.com | NA,NA | 23663407,23663407 | CHEMBL19299,CHEMBL19299 |
| lumiracoxib | cyclooxygenase inhibitor | Withdrawn | Wikipedia | DB01283 | NA | CHEMBL404108 |
| meclofenamic-acid,meclofenamic-acid | cyclooxygenase inhibitor,prostanoid receptor antagonist | Launched,Launched | FDA Orange Book: meclofenamate sodium,FDA Orange Book: meclofenamate sodium | DB00939,DB00939 | 23663959,23663959 | CHEMBL509,CHEMBL509 |
| mefenamic-acid | cyclooxygenase inhibitor | Launched | FDA Orange Book: mefenamic acid | DB00784 | 4044 | CHEMBL686 |
| meloxicam | cyclooxygenase inhibitor | Launched | FDA Orange Book: meloxicam | DB00814 | 10291556 | CHEMBL599 |
| mesalazine,mesalazine,mesalazine | cyclooxygenase inhibitor,lipoxygenase inhibitor,prostanoid receptor antagonist | Launched,Launched,Launched | FDA Orange Book: mesalamine,FDA Orange Book: mesalamine,FDA Orange Book: mesalamine | DB00244,DB00244,DB00244 | 4075,4075,4075 | CHEMBL704,CHEMBL704,CHEMBL704 |
| metoxibutropate | cyclooxygenase inhibitor | Launched | PubMed | NA | NA | NA |
| nabumetone | cyclooxygenase inhibitor | Launched | FDA Orange Book: nabumetone | DB00461 | 4409 | CHEMBL1070 |
| naproxen | cyclooxygenase inhibitor | Launched | FDA Orange Book: naproxen | DB00788 | 13022368105923675324 | CHEMBL154 |
| nepafenac | cyclooxygenase inhibitor | Launched | FDA Orange Book: nepafenac | DB06802 | NA | CHEMBL1021 |
| niflumic-acid | cyclooxygenase inhibitor | Launched | drugs.com | DB04552 | 4488 | CHEMBL63323 |
| nimesulide | cyclooxygenase inhibitor | Launched | drugs.com | DB04743 | 4495 | CHEMBL56367 |
| nitroflurbiprofen | cyclooxygenase inhibitor | Preclinical | PubMed Search | NA | NA | NA |
| NO-ASA | cyclooxygenase inhibitor | Phase 2 | ClinicalTrials | DB12445 | 119032 | CHEMBL374385 |
| olsalazine | cyclooxygenase inhibitor | Launched | FDA Orange Book: olsalazine sodium | DB01250 | NA | CHEMBL425 |
| oxaprozin | cyclooxygenase inhibitor | Launched | FDA Orange Book: oxaprozin | DB00991 | 4614 | CHEMBL1071 |
| paracetamol | cyclooxygenase inhibitor | Launched | FDA Orange Book: acetaminophen | DB00316 | 1983 | CHEMBL112 |
| parecoxib | cyclooxygenase inhibitor | Launched | drugs.com | DB08439 | 119828 | CHEMBL1206690 |
| phenazone | cyclooxygenase inhibitor | Launched | Wikipedia | DB01435 | 220698889 | CHEMBL277474 |
| phenylbutazone,phenylbutazone | cyclooxygenase inhibitor,prostanoid receptor antagonist | Withdrawn,Withdrawn | Wikipedia,Wikipedia | DB00812,DB00812 | 4781,4781 | CHEMBL101,CHEMBL101 |
| piceatannol | SYK inhibitor | Preclinical | PubMed Search | DB08399 | 4813 | CHEMBL69863 |
| piroxicam | cyclooxygenase inhibitor | Launched | FDA Orange Book: piroxicam | DB00554 | 22723678 | CHEMBL527 |
| proglumetacin | cyclooxygenase inhibitor | Launched | drugs.com | NA | NA | CHEMBL215825 |
| propacetamol | cyclooxygenase inhibitor | Launched | drugs.com | DB09288 | NA | CHEMBL1851805 |
| proquazone | cyclooxygenase inhibitor | Launched | Unexpected Source | DB13649 | NA | CHEMBL268501 |
| pterostilbene,pterostilbene | cyclooxygenase inhibitor,PPAR receptor agonist | Phase 2/Phase 3,Phase 2/Phase 3 | ClinicalTrials,ClinicalTrials | NA,NA | 5281727,5281727 | CHEMBL83527,CHEMBL83527 |
| resveratrol,resveratrol | cytochrome P450 inhibitor,SIRT activator | Launched,Launched | drugs.com,drugs.com | DB02709,DB02709 | 445154,445154 | CHEMBL165,CHEMBL165 |
| rofecoxib | cyclooxygenase inhibitor | Withdrawn | Wikipedia | DB00533 | 5090 | CHEMBL122 |
| rutaecarpine | cyclooxygenase inhibitor | Preclinical | PubMed Search | NA | NA | CHEMBL85139 |
| RWJ-67657 | MAP kinase inhibitor | Phase 1 | PubMed | NA | NA | CHEMBL190333 |
| salicylic-acid,salicylic-acid | cyclooxygenase inhibitor,prostanoid receptor antagonist | Launched,Launched | FDA Orange Book: aminosalicylic acid,FDA Orange Book: aminosalicylic acid | DB00936,DB00936 | NA,NA | CHEMBL424,CHEMBL424 |
| sasapyrine | NFkB pathway inhibitor | Launched | drugs.com | DB01399 | NA | CHEMBL154111 |
| SB-239063 | p38 MAPK inhibitor | Preclinical | PubMed Search | NA | 5166 | CHEMBL97162 |
| SC-236 | cyclooxygenase inhibitor | Preclinical | PubMed Search | DB14059 | NA | CHEMBL282093 |
| sulfasalazine | cyclooxygenase inhibitor | Launched | FDA Orange Book: sulfasalazine | DB00795 | 5359476 | CHEMBL421 |
| sulindac | cyclooxygenase inhibitor | Launched | FDA Orange Book: sulindac | DB65 | 154888715488855352624 | CHEMBL1577 |
| suprofen | cyclooxygenase inhibitor | Withdrawn | Wikipedia | DB87 | 5359 | CHEMBL253765 |
| tenoxicam | cyclooxygenase inhibitor | Launched | drugs.com | DB00469 | 54677971 | CHEMBL302795 |
| thioctic-acid | reducing agent | Launched | ClinicalTrials | DB166 | NA | CHEMBL1234071 |
| tiaprofenic-acid | cyclooxygenase inhibitor | Launched | Wikipedia | DB16 | 5468 | CHEMBL1362630 |
| tolmetin | cyclooxygenase inhibitor | Launched | FDA Orange Book: tolmetin sodium | DB00500 | 5509 | CHEMBL1020 |
| trichlormethiazide | chloride channel blocker | Launched | FDA Orange Book: trichlormethiazide | DB121 | NA | CHEMBL154 |
| triflusal,triflusal,triflusal | cyclooxygenase inhibitor,platelet aggregation inhibitor,thromboxane synthase inhibitor | Launched,Launched,Launched | drugs.com,drugs.com,drugs.com | DB08814,DB08814,DB08814 | 9458,9458,9458 | CHEMBL1332032,CHEMBL1332032,CHEMBL1332032 |
| tropesin | cyclooxygenase inhibitor | Launched | docslide | NA | NA | NA |
| tryptanthrin | cyclooxygenase inhibitor | Preclinical | PubMed Search | NA | NA | CHEMBL306946 |
| ufenamate | cyclooxygenase inhibitor | Launched | drugs.com | NA | NA | CHEMBL2105605 |
| valdecoxib | cyclooxygenase inhibitor | Withdrawn | Wikipedia | DB00580 | 119607 | CHEMBL865 |
| vedaprofen | anti-inflammatory agent | Launched | FDA Orange Book: vedaprofen | NA | NA | NA |
10 best STRING interaction
-
Endoplasmic reticulum
- Microsome membrane 1 Publication; Peripheral membrane protein
- Endoplasmic reticulum membrane 1 Publication; Peripheral membrane protein
-
Nucleus
- Nucleus inner membrane 1 Publication; Peripheral membrane protein
- Nucleus outer membrane 1 Publication; Peripheral membrane protein
Note: Detected on the lumenal side of the endoplasmic reticulum and nuclear envelope.1 Publication
-
Endoplasmic reticulum
- endoplasmic reticulum Source: ParkinsonsUK-UCL
- endoplasmic reticulum lumen Source: ParkinsonsUK-UCL
- endoplasmic reticulum membrane Source: Reactome
-
Nucleus
- nuclear inner membrane Source: UniProtKB
- nuclear outer membrane Source: UniProtKB
-
Plasma Membrane
- caveola Source: Ensembl
-
Other locations
- cytoplasm Source: UniProtKB
- neuron projection Source: MGI
- protein-containing complex Source: Ensembl
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Extracellular region or secreted
- Secreted 2 Publications
-
Endoplasmic reticulum
- endoplasmic reticulum Source: LIFEdb
-
Extracellular region or secreted
- basement membrane Source: Ensembl
- extracellular region Source: GO_Central
- extracellular space Source: UniProtKB
-
Plasma Membrane
- plasma membrane Source: GOC
-
Other locations
- cell surface Source: Ensembl
- neuromuscular junction Source: Ensembl
- perinuclear region of cytoplasm Source: Ensembl
- postsynapse Source: Ensembl
- presynapse Source: Ensembl
- protein-containing complex Source: UniProtKB
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Endosome
- Late endosome 1 Publication
-
Other locations
-
Endosome
- late endosome Source: UniProtKB
- multivesicular body membrane Source: UniProtKB
-
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
-
Golgi apparatus
- Golgi stack Source: UniProtKB
-
Plasma Membrane
- apical plasma membrane Source: Ensembl
- plasma membrane Source: Reactome
-
Other locations
- anchored component of synaptic vesicle membrane Source: Ensembl
- axon cytoplasm Source: GOC
- melanosome Source: UniProtKB
- platelet dense granule membrane Source: Reactome
- secretory granule Source: GO_Central
- trans-Golgi network transport vesicle Source: UniProtKB
- zymogen granule membrane Source: Ensembl
TO BE DONE...
TO BE DONE...
10 best STRING interaction
-
Other locations
- Cytoplasm 1 Publication
- Lipid droplet 1 Publication
-
Cytosol
- cytosol Source: HPA
-
Nucleus
- nucleoplasm Source: HPA
-
Other locations
- lipid droplet Source: UniProtKB
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| ginsenoside-RE | anti-inflammatory agent | Phase 1 | ClinicalTrials | NA | NA | NA |
10 best STRING interaction
-
Nucleus
- Nucleus By similarity
-
Cytosol
- cytosol Source: GO_Central
-
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleoplasm Source: GO_Central
- nucleus Source: CACAO
-
Other locations
- transcription regulator complex Source: Ensembl
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| brigatinib,brigatinib | ALK tyrosine kinase receptor inhibitor,EGFR inhibitor | Launched,Launched | DailyMed,DailyMed | DB12267,DB12267 | NA,NA | CHEMBL3545311,CHEMBL3545311 |
| crizotinib | ALK tyrosine kinase receptor inhibitor | Launched | FDA Orange Book: crizotinib | DB08865 | 11626560 | CHEMBL601719 |
| entrectinib,entrectinib | ALK tyrosine kinase receptor inhibitor,proto-oncogene tyrosine protein kinase inhibitor | Launched,Launched | ClinicalTrials,ClinicalTrials | DB11986,DB11986 | NA,NA | CHEMBL1983268,CHEMBL1983268 |
| lorlatinib | ALK tyrosine kinase receptor inhibitor | Launched | DailyMed | NA | NA | CHEMBL328683 |
| PF-06463922 | ALK tyrosine kinase receptor inhibitor | Launched | ClinicalTrials | NA | NA | NA |
| repotrectinib | receptor tyrosine protein kinase inhibitor | Phase 1/Phase 2 | ClinicalTrials | NA | NA | NA |
10 best STRING interaction
-
Plasma membrane
- Cell membrane Curated; Single-pass type I membrane protein Curated
-
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
-
Other locations
- cell surface Source: Ensembl
- membrane Source: ProtInc
- perinuclear region of cytoplasm Source: Ensembl
- receptor complex Source: GO_Central
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Golgi apparatus
- Golgi apparatus membrane 1 Publication; Multi-pass membrane protein Sequence analysis
-
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein Sequence analysis
-
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
- endoplasmic reticulum membrane Source: UniProtKB
- integral component of endoplasmic reticulum membrane Source: UniProtKB
-
Golgi apparatus
- Golgi membrane Source: UniProtKB
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Extracellular region or secreted
- Secreted 1 Publication
-
Other locations
- secretory vesicle lumen 1 Publication
- Perikaryon 1 Publication
-
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular space Source: UniProtKB
-
Other locations
- cytoplasmic vesicle lumen Source: UniProtKB
- neuronal cell body Source: UniProtKB
- perikaryon Source: UniProtKB-SubCell
- secretory granule lumen Source: Ensembl
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleolus Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
-
Other locations
- cytoplasm Source: UniProtKB-SubCell
- transcription regulator complex Source: UniProtKB
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Cytosol
- cytosol Source: HPA
-
Nucleus
- heteromeric SMAD protein complex Source: GO_Central
- nuclear chromatin Source: NTNU_SB
- nucleoplasm Source: HPA
- nucleus Source: BHF-UCL
-
Other locations
- cytoplasm Source: BHF-UCL
- SMAD protein complex Source: BHF-UCL
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Nucleus
- Nucleus By similarity
-
Cytosol
- cytosol Source: UniProtKB
-
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
-
Other locations
- cytoplasm Source: UniProtKB
- transcription regulator complex Source: BHF-UCL
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| bosutinib,bosutinib,bosutinib | Abl kinase inhibitor,Bcr-Abl kinase inhibitor,SRC inhibitor | Launched,Launched,Launched | FDA Orange Book: bosutinib monohydrate,FDA Orange Book: bosutinib monohydrate,FDA Orange Book: bosutinib monohydrate | DB06616,DB06616,DB06616 | 5328940,5328940,5328940 | CHEMBL288441,CHEMBL288441,CHEMBL288441 |
10 best STRING interaction
-
Cytosol
- cytosol Source: HPA
-
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
-
Golgi apparatus
- Golgi apparatus Source: UniProtKB
-
Nucleus
- nucleolus Source: HPA
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
-
Other locations
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Other locations
- synaptic vesicle membrane 1 Publication; Multi-pass membrane protein Sequence analysis
- synaptosome 1 Publication
-
Plasma Membrane
- presynaptic membrane Source: Ensembl
-
Other locations
- excitatory synapse Source: Ensembl
- integral component of synaptic vesicle membrane Source: UniProtKB
- neuromuscular junction Source: Ensembl
- neuron projection Source: UniProtKB
- perinuclear region of cytoplasm Source: Ensembl
- presynaptic active zone Source: GO_Central
- Schaffer collateral - CA1 synapse Source: Ensembl
- synaptic vesicle Source: ParkinsonsUK-UCL
- synaptic vesicle membrane Source: GO_Central
- terminal bouton Source: Ensembl
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| ONC201,ONC201 | AKT inhibitor,MAP kinase inhibitor | Phase 2,Phase 2 | ClinicalTrials,ClinicalTrials | DB14844,DB14844 | NA,NA | NA,NA |
10 best STRING interaction
-
Plasma membrane
- Cell membrane 1 Publication; Single-pass type II membrane protein Curated
-
Extracellular region or secreted
- Secreted 1 Publication
Note: Exists both as membrane-bound and soluble form.1 Publication
-
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
-
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Nucleus
- Nucleus 2 Publications
-
Endoplasmic reticulum
- rough endoplasmic reticulum Source: Ensembl
-
Mitochondrion
- mitochondrion Source: GOC
-
Nucleus
- nuclear chromatin Source: BHF-UCL
- nucleoplasm Source: UniProtKB
- nucleus Source: UniProtKB
-
Other locations
- cytoplasm Source: MGI
- dendrite Source: Ensembl
- protein-containing complex Source: Ensembl
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Cytosol
- cytosol Source: Reactome
-
Golgi apparatus
- Golgi apparatus Source: HPA
-
Mitochondrion
- mitochondrion Source: GOC
-
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleoplasm Source: HPA
- nucleus Source: AgBase
-
Other locations
- cell junction Source: HPA
- intracellular membrane-bounded organelle Source: HPA
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| carbimazole | antithyroid agent | Launched | Wikipedia | DB00389 | 31072 | CHEMBL508102 |
| methimazole | antithyroid agent | Launched | FDA Orange Book: methimazole | DB00763 | 1349907 | CHEMBL1515 |
| propylthiouracil | thyroid peroxidase inhibitor | Launched | FDA Orange Book: propylthiouracil | DB00550 | 657298 | CHEMBL1518 |
10 best STRING interaction
-
Other locations
-
Other locations
-
Extracellular region or secreted
- extracellular space Source: UniProtKB
-
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: Reactome
-
Other locations
- cell surface Source: UniProtKB-SubCell
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| 2,4-dinitrophenol | ATP synthase inhibitor | Preclinical | PubMed Search | DB04528 | NA | CHEMBL273386 |
| tafamidis-meglumine | transthyretin amyloid inhibitor | Launched | Wikipedia | DB11644 | NA | CHEMBL2103837 |
| tolcapone | catechol O methyltransferase inhibitor | Withdrawn | Wikipedia | DB00323 | 4659569 | CHEMBL1324 |
10 best STRING interaction
-
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
- extracellular space Source: UniProtKB
-
Lysosome
- azurophil granule lumen Source: Reactome
-
Other locations
- protein-containing complex Source: Ensembl
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Lysosome
- Lysosome membrane 1 Publication; Single-pass type IV membrane protein Curated
-
Endosome
- Early endosome membrane 2 Publications; Single-pass type IV membrane protein Curated
- Late endosome membrane 1 Publication; Single-pass type IV membrane protein Curated
-
Plasma membrane
- Cell membrane By similarity; Single-pass type IV membrane protein Curated
Note: Perinuclear vesicular structures of the early and late endosomes, coated pits, and trans-Golgi (By similarity). Sub-tight junctional domain in retinal pigment epithelium cells. Midbody region during cytokinesis. Lumenal oriented, apical membranes of nephric tubular cell (By similarity). Cycles through the apical but not through the basolateral plasma membrane (By similarity). Apical region of acinar cells; in zymogen granule membranes (By similarity).By similarity
-
Cytosol
- cytosol Source: UniProtKB
-
Endosome
- early endosome Source: ProtInc
- early endosome membrane Source: UniProtKB-SubCell
- late endosome membrane Source: UniProtKB
- recycling endosome Source: UniProtKB
- recycling endosome membrane Source: Reactome
-
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
-
Lysosome
- azurophil granule membrane Source: UniProtKB
- lysosomal membrane Source: UniProtKB
-
Plasma Membrane
- plasma membrane Source: UniProtKB
-
Other locations
- clathrin-coated vesicle membrane Source: Reactome
- cytoplasm Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
- membrane Source: UniProtKB
- mucin granule Source: UniProtKB
- perinuclear region of cytoplasm Source: UniProtKB
- phagocytic vesicle membrane Source: Reactome
- secretory granule membrane Source: UniProtKB
- SNARE complex Source: UniProtKB
- specific granule membrane Source: Reactome
- tertiary granule membrane Source: Reactome
- vesicle Source: UniProtKB
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Cytosol
- cytosol Source: HPA
-
Nucleus
- nucleus Source: BHF-UCL
-
Other locations
- bicellular tight junction Source: BHF-UCL
- cytoplasm Source: ProtInc
- perinuclear region of cytoplasm Source: BHF-UCL
TO BE DONE...
TO BE DONE...
| Compound | MoA i | Clinical Status | Resources | DrugBank | PubChem | ChEMBL |
|---|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA | NA |
10 best STRING interaction
-
Nucleus
- nuclear body Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
-
Other locations
- cytoplasm Source: UniProtKB
TO BE DONE...
TO BE DONE...